Are you seeking a rewarding career in biopharma research, protein sciences, or metabolic disease drug discovery? Merck & Co., Inc. offers multiple exciting job opportunities at its South San Francisco, California site for experienced scientists and leaders.

This blog post covers career openings for roles focused on drug discovery, biologics characterization, and antibody discovery. Read on to learn about the key responsibilities, qualifications, and application process.
1. Associate Principal Scientist – Metabolic Diseases
📍 Location: South San Francisco, CA
🧬 Focus Area: Cardiometabolic Disease Research, including CNS regulation, energy balance, and cellular metabolism.
Key Requirements:
- 🎓 Education: Ph.D. in Biology, Physiology, or related fields with 4+ years of industry experience.
- 🧪 Expertise: Proficiency in target identification, in vitro/in vivo assays, and preclinical drug development.
- 📊 Skills: Strong data analysis and communication skills to present findings effectively.
👉 Click Here to Apply Now and lead metabolic research for groundbreaking therapies! 🌍
2. Director – Discovery Biologics, Protein Sciences, and Analytical Characterization
📍 Location: South San Francisco, CA
🔬 Focus Area: Biologics development, protein characterization, and analytical methods.
Key Requirements:
- 🎓 Education: Ph.D. with 8+ years of industry experience in protein sciences and biologics.
- 🧪 Expertise: Proficiency in analytical tools like HPLC, SPR, CE-SDS, and molecular interaction analysis.
- 🏆 Leadership: Proven success in team management, project leadership, and cross-functional collaboration.
👉 Click Here to Apply Now and lead protein sciences innovation at Merck! 🚀
3. Senior Scientist – Biochemistry and Biophysics
📍 Location: South San Francisco, CA
🧪 Focus Area: Biophysical assay development, lead discovery, and radioligand binding.
Key Requirements:
- 🎓 Education: Ph.D. or Master’s in Biochemistry, Biophysics, or related fields.
- 🧫 Expertise: Hands-on experience with assay development, automation, and data visualization tools.
- 📊 Skills: Strong analytical mindset with proficiency in Excel, GraphPad Prism, and related software.
👉 Click Here to Apply Now and join the team advancing biophysical innovations! 🔬
4. Scientist – In Vivo Antibody Discovery, Molecular Discovery
📍 Location: South San Francisco, CA
🧪 Focus Area: Antibody discovery, screening assays, and molecular biology tools.
Key Requirements:
- 🎓 Education: Bachelor’s (2+ years) or Master’s in Molecular Biology, Cell Biology, or related fields.
- 🧫 Expertise: Hands-on experience with B-cell screening, NGS platforms, and high-throughput screening assays.
- 📊 Skills: Strong data interpretation and visualization capabilities using ELISA, FACS, and Flow Cytometry.
👉 Click Here to Apply Now and drive antibody discovery innovations! 💉
5. Scientist – Discovery Biology / In Vivo Ophthalmology
📍 Location: South San Francisco, CA
👁️ Focus Area: Ophthalmology research, disease models, and drug discovery.
Key Requirements:
- 🎓 Education: Bachelor’s (3+ years) or Master’s in Cell Biology, Molecular Biology, or Neuroscience.
- 🧫 Expertise: Hands-on experience with retinal imaging, fluorescein angiography, and OCT technologies.
- 📊 Skills: Proficient in analyzing data using Spotfire, GraphPad Prism, and similar tools.
👉 Click Here to Apply Now and join the mission to advance ophthalmology therapies! 👓
Why Choose Merck?
- 🌍 Global Reach: Work on therapies that impact lives worldwide.
- 📈 Career Growth: Continuous development programs and learning resources.
- 💼 Flexible Work Models: Hybrid work setups for better work-life balance.
- 🌿 Diverse Environment: Inclusive teams fostering creativity and collaboration.
Eligibility and International Applicants 🌎
These positions are primarily based in the United States (South San Francisco, CA).
Visa Sponsorship:
- Available for select roles. Check specific job listings for eligibility criteria.
International Applicants:
- Interested candidates outside the U.S. can explore global opportunities at Merck’s International Career Portal:
👉 MSD Careers Page
Why Choose Merck & Co., Inc.?
- Global Impact: Be part of life-changing innovations in biopharma research.
- Advanced Technologies: Work with AI/ML tools, protein sciences, and drug discovery platforms.
- Career Growth: Gain exposure to cutting-edge R&D and professional development programs.
- Inclusive Culture: Thrive in a diverse and collaborative environment.
- Comprehensive Benefits: Competitive salaries, bonuses, insurance, and retirement plans.
How to Apply?
Interested candidates can apply directly through the Merck Careers Portal.
For global roles, visit the MSD Careers Page to explore additional opportunities outside the USA.
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